From the Automatic Control Laboratory at ETH Zürich, a project on automating anaesthesia:
The first steps to introduce feedback control in anesthesia were undertaken more than ten years ago. The project encompasses all control system aspects, namely
design of experiments and open loop identification
modeling of biological complex systems
statistical analysis of large population data
control design and simulation
pilot studies and clinical routine validation
Automated Control of Anesthesia was successfully tested during surgery on more than 200 patients and 650 hours.
The successful application of our ideas is made possible by the close cooperation with: the Department of Anaesthesiology at the University Hospital in Berne (Inselspital), where volunteers are enrolled for model identification and controllers are validated in clinical studies.
Papers:
Eleonora Zanderigo, Valentina Sartori, Gorazd Sveticic,Thomas Bouillon, Peter Schumacher, Michele Curatolo, Manfred Morari, A new model for drug interactions and optimal drug dosing, 27th Annual Conference of the IEEE Engineering in Medicine and Biology, January 2006.
Eleonora Zanderigo, Antonello Caruso, Thomas Bouillon, Martin Luginbuhl, Manfred Morari, Pharmacodynamic modelling of drug-induced ventilatory depression and automatic drug dosing in conscious sedation, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.
Antonello L.G. Caruso, Thomas W. Bouillon, Peter M. Schumacher, Martin Luginbuhl, Manfred Morari, Drug-induced respiratory depression: an integrated model of drug effects on the hypercapnic and hypoxic drive, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, August 2007.
Antonello L.G. Caruso, Thomas W. Bouillon, Peter M. Schumacher, Manfred Morari, On the modeling of drug induced respiratory depression in the non-steady-state, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, August 2008.
Antonello L. G. Caruso, Thomas W. Bouillon, Peter M. Schumacher, Eleonora Zanderigo, Manfred Morari, Control of drug administration during monitored anesthesia care, IEEE Transactions on Automation Science and Engineering, Volume 6, Issue 2, April 2009.
Antonello L. G. Caruso, Manfred Morari, Model predictive control for propofol sedation, World Congress on Medical Physics and Biomedical Engineering, September 2009.
Theses:
Valentina Sartori, Optimal modeling and drug administration for anesthesia in clinical practice, ETH Zürich, 2006.
Eleonora Zanderigo, Optimal administration of analgesics in humans, ETH Zürich, 2006.
Antonello L. G. Caruso, Personalized drug dosing through modeling and feedback, ETH Zürich, 2009.